Endocrine Abstracts

Introduction: In patients with cured Cushing’s syndrome, comorbidities often persist after remission of glucocorticoid excess. Here we investigate long-term comorbidities in patients with Cushing’s syndrome in remission, and their relationship to metabolic and hormonal markers at the initial diagnosis of the disease.Methods/design: We evaluated 118 patients with cured Cushing’s syndrome (55 Cushing’s disease, 55 adrenal Cushing’s...

We have recently shown that patients with growth hormone (GH) excess (acromegaly) exhibit inadequately low intrahepatic lipid content (IHL) despite marked insulin resistance. GH might increase mitochondrial oxidation capacity thereby counteracting ectopic lipid accumulation; however, up-regulation of mitochondrial function has been reported in early stages of non-alcoholic fatty liver disease. Up to now, data on mitochondrial activity in patients with acromegaly are missing.</...

Introduction: Cushing’s syndrome is associated with significant chronic and acute complications including acute thromboembolic and cardiovascular events. We aimed to study the prevalence and predictors of acute and perioperative complications in patients with active Cushing’s syndrome.Methods: The prevalence, predictors and outcomes of acute, life-threatening and perioperative complications were evaluated in a cohort of patients with active b...